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Clinical outcome of osteoporotic vertebral fracture (OVF) patients is influenced by the severity of the fracture. OVFs are commonly associated with age, sex, comorbidities, and factors, such as the presence of metastases. Less is known about the outcome of patients with mild fractures as compared to those with severe fractures. Our objective was to evaluate risk factors for mortality of OVF patients with mild and severe fractures. We performed a multicenter, observational, retrospective study of patients with OVFs (T4-L4) treated with vertebroplasty or kyphoplasty from January 1, 2010, through August 31, 2012, in seven academic centers. We included patients who had a baseline assessment (≤3 months before treatment) and a follow-up assessment (3-12 months after treatment) and who had a follow-up of at least 12 months and no evidence of metastases, multiple myeloma, or other primary bone diseases. OVF severity was defined at the time of the index fracture as severe (vertebral body height loss ≥50%) or mild (vertebral body height loss
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